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  • Brain
  • Neurological
  • Skull Base
  • Spinal


Dr Enrico Clarke is a Consultant Clinical Oncologist based at the Rutherford Cancer Centre in Thames Valley, specialising in the treatment of patients with brain tumours.

He was born and educated in Italy and trained in Medicine at University Sapienza in Rome with fellowships at the Royal Marsden Hospital, University College Hospital, and observership at M.D. Anderson Cancer Centre in Texas.

Dr Clarke has worked as a consultant in neuro-oncology since February 2019 and has worked as a clinical fellow at the Clatterbridge Cancer Centre and at The Royal Marsden Hospital.

He provides radiotherapy and systemic treatment for brain, skull-base, pituitary and spinal tumours and participates in the ongoing development and delivery of proton beam therapy.

Dr Clarke loves music, art and travelling. He enjoys physical activity including cycling and hiking especially on the South Coast of England.

Areas of interest:

Neuro-Oncology, Skull-base, Pituitary, Spinal tumours.

Research Interests:

Dr Clarke has an interest in technical developments in radiotherapy, including advanced treatment techniques such as stereotactic radiotherapy, intensity-modulated radiotherapy, image-guided radiotherapy and proton beam therapy with a particular focus on the treatment of benign and malignant brain tumours.


  • July 2008 Graduated with Honours at the Second Faculty of Medicine, “Sapienza” University of Rome. Dissertation: “Radiosurgery for brain metastases”.
  • June 2014 Completed training in Radiation Oncology at Sant’Andrea Hospital, University of Rome "Sapienza", 70/70 With Honours,
    Dissertation: “Repeat Radiosurgery for Progressive Brain Metastases".
  • Proton Therapy Clinical Education Program at the University of Pennsylvania completed on 04/05/2021.


  • BNOS


  • Clarke E, Brock J, Soldà F, Gupta S, Brada M. The impact of brain metastases on the clinical service in a cancer center. J Palliat Med. 2013 Aug;16(8):836-7.
  • Clarke E, Curtis J, Brada M.
    Incidence and evolution of imaging changes on cone-beam CT during and after radical radiotherapy for non-small cell lung cancer.
    Radiother Oncol. 2019 Mar;132:121-126. doi: 10.1016/j.radonc.2018.12.009. Epub 2018 Dec 31.
    PMID: 30825960
  • Minniti G, Clarke E, Lanzetta G, Osti MF, Trasimeni G, Bozzao A, Romano A, Enrici RM. Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis. Radiat Oncol. 2011 May 15;6:48.
  • Minniti G, Clarke E, Scaringi C, Enrici RM. Stereotactic radiotherapy and radiosurgery for non-functioning and secreting pituitary adenomas. 2016 Jul-Aug;21(4):370-8.
  • Minniti G, Scaringi C, Paolini S, Clarke E, Cicone F, Esposito V, Romano A, Osti M, Enrici RM.
    2016 Jan;126(1):91-7. doi: 10.1007/s11060-015-1937-4.
  • Minniti G, Esposito V, Clarke E, Scaringi C, Bozzao A, Falco T, De Sanctis V, Enrici MM, Valeriani M, Osti MF, Enrici RM. Fractionated stereotactic radiosurgery for patients with skull base metastases from systemic cancer involving the anterior visual pathway. Radiat Oncol. 2014 May
    8;9:110. doi: 10.1186/1748-717X-9-110.
  • Minniti G, D'Angelillo RM, Scaringi C, Trodella LE, Clarke E, Matteucci P, Osti MF, Ramella S, Enrici RM, Trodella L. Fractionated stereotactic radiosurgery for patients with brain metastases. J Neurooncol. 2014 Apr;117(2):295-301. doi: 10.1007/s11060-014-1388-3.
  • Rosenfelder NA, Corsini L, McNair H, Pennert K, Aitken A, Lamb CM, Long M, Clarke E, Murcia M, Schick U, Burke K, Ashley S, Khoo V, Brada M. Comparison of setup accuracy and intrafractionmotion using stereotactic frame versus 3-point thermoplastic mask-based immobilization for fractionated cranial image guided radiation therapy. Pract Radiat Oncol. 2013 Jul-Sep;3(3):171-179.
  • Minniti G, Esposito V,Clarke E, Scaringi C, Lanzetta G, Salvati M, Raco A, Bozzao A, Maurizi Enrici R. Multidose stereotactic radiosurgery (9 Gy × 3) of the postoperative resection cavity for treatment of large brain metastases. Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):623-9.
  • Minniti G, Esposito V,Clarke E, Scaringi C, Bozzao A, Lanzetta G, De Sanctis V, Valeriani M, Osti M, Enrici RM. Stereotactic radiosurgery in elderly patients with brain metastases. J Neurooncol 2013 Feb;111(3):319-25.
  • Minniti G, Scaringi C, Clarke E, Valeriani M, Osti M, Enrici RM. Frameless linac-based stereotactic radiosurgery (SRS) for brain metastases: analysis of patient repositioning using a mask fixation system and clinical outcomes. Radiat Oncol. 2011 Nov 16;6:158.
  • Minniti G, Clarke E, Cavallo L, Osti MF, Esposito V, Cantore G, Cappabianca P, Enrici RM.
    Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas. Radiat Oncol. 2011 Apr 12;6:36.
  • Minniti G, Salvati M, Muni R, Lanzetta G, Osti MF, Clarke E, Costa A, Bozzao A, Trasimeni G, Enrici RM. Stereotactic radiosurgery plus whole-brain radiotherapy for treatment of multiple metastases from non-small cell lung cancer. Anticancer Res. 2010 Jul;30(7):3055-61.
  • Minniti G, Valeriani M, Clarke E, D'Arienzo M, Ciotti M, Montagnoli R, Saporetti F, Enrici RM.
    Fractionated stereotactic radiotherapy for skull base tumors: analysis of treatment accuracy using a stereotactic mask fixation system. Radiat Oncol. 2010 Jan 13;5:1.


  1. Dr Enrico Clarke does not hold a share or financial interest in the Rutherford Cancer Centres or another Rutherford Health plc company.
  2. Dr Enrico Clarke does not have a share or financial interest in equipment used at the Rutherford Cancer Centres or another Rutherford Health plc company.
  3. Dr Enrico Clarke does not hold any paid advisory role(s) at the Rutherford Cancer Centres or on behalf of Rutherford Cancer Centres or Rutherford Health plc.

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